Ototoksisitas Aminoglikosida

  • Fransiska Fransiska Fakultas Kedokteran, Universitas Surabaya

Abstract

Abstract — Aminoglicoside are categorized as cochleotoxic and vestibulotoxic drugs that can cause patients to experience hearing loss or vertigo, depends on what type of aminoglicoside consumed. This paper discuss type, pharmaceutical preparation, pharmacokinetics, work mechanism and clinical use of aminoglycoside. How to diagnose, treatment, and also how to prevent aminoglicoside ototoxicity are also explained further in this paper.


Abstrak— Golongan obat aminoglikosida mampu menyebabkan kokleotoksik, maupun vestibulotoksik sehingga penderita mengalami penurunan pendengaran atau vertigo. Hal tersebut tergantung dari jenis aminoglikosida yang dikonsumsi. Tulisan ini membahas berbagai jenis aminoglikosida, sediaan, farmakokinetik, mekanisme kerja, dan penggunaannya secara klinis. Diagnosis yang  meliputi anamnesis, pemeriksaan fisik, pemeriksaan penunjang, terapi, dan pencegahan ototoksisitas yang disebabkan oleh aminoglikosida turut dipaparkan lengkap.

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References


  1. Chang KW. Ototoxicity. In: Johnson JT, Rosen CA, Newlands S, Amin M, Branstetter B, Casselbrant M, et al, eds. Bailey’s head and neck surgery–otolaryngology. 5th ed. Vol 2. Philadelphia: Lippincot Williams & Wilkins; 2014. p. 2542-8.


  2. Pagkalis S, Mantadakis E, Mavros MN, Ammari C, Falagas ME. Pharmacological considerations for the proper clinical use of aminoglycosides. Drugs 2011; 71 (17):2277-94.


  3. Blakley BW. Intratympanic gentamicin in the treatment of meniere’s disease. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 191-5.


  4. Ghodsian NF. Genetic factors in aminoglycoside ototoxicity. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 144-9.


  5. Roland NJ, Mcrae RDR, Mccombe AW. Ototoxicity. In: Roland NJ, Mcrae RDR, Mccombe AW, eds. Key topics in otolaryngology and head and neck surgery. 2nd ed. Oxford: Bios scientific publishers Ltd; 2001. p. 229-30.


  6. Iurato S. Ototoxicity. In: European manual of medicine in otorhinolaryngology-head and neck surgery. 1st ed. Berlin: Springer; 2010. p. 129-30.


  7. Roland PS, Pawlowski KS. Ototoxicity. In: Wackym PA, Snow JBS, eds. Ballenger’s otorhinolaryngology head and neck surgery. 17th ed. Connecticut: BC decker Inc; 2009. p. 273-6.


  8. Tange RA. Ototoxicity. In: Dhingra PL, ed. Disease of ear, nose and throat. 4th ed. India: Elsevier; 2007. p. 34-5.


  9. Fairbanks DNF. Ototoxicity, prevention and monitoring. In: Fairbanks DNF, ed. Pocket guide to antimicrobial therapy in otolaryngology – head and neck surgery. 13th ed. Alexandria: American Academy of


  10. Al-Malky G, Suri R, Dawson SJ, Sirimanna T, Kemp D. Aminoglycoside antibiotics cochleotoxicity in paediatric cyctic fibrosis (cf) patients: a study using extended high-frequency audiometry and distortion product otoacoustic emissions. International Journal of Audiology 2011; 50:112-22.


  11. Schacht J. Mechanisms for aminoglycoside ototoxicity: basic science research. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 93-8.


  12. Mylonas I. Antibiotic chemotherapy during pregnancy and lactation period: aspects for consideration. Archieve Gynecology Obstetric 2011: 287:7-18.


  13. O’leary S. Ototoxicity. In: Gleeson M, Browning G, Burha MJ, Clarke R, Hibbert J, Jones NS, et al, eds. Scott- brown’s otorhinolaryngology head & neck surgery. 7th ed. London: Edward Arnold Ltd; 2008. p. 3567-73.


  14. Zarandy MM, Rutka J. Ototoxicity. In: Zarandy MM, Rutka J, eds. Diseases of the inner ear: a clinical, radiologic & pathologic atlas. 1st ed. Berlin: Springer; 2010. p. 85-8.


  15. Probst R. Inner ear and retrocochlear disorder. In: Probst R, Grevers G, Iro H, eds. Basic otorhinolaryngology, a step-by-step learning guide. New York: Thieme; 2006. p. 263-4.


  16. Shin JJ, Lin MY, Rauch SD. Ototopical neomycin: impact on post- treament hearing. In: Shin JJ, Hartnick CJ, Randolph GW, eds. Evidence-based otolaryngology. 1st ed. New York: Springer; 2008. p. 259-61.


  17. Kisilevsky VE, Tomlinson RD, Ranalli PJ, Prepageran N. Monitoring vestibular toxicity. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004: p. 161-8.


  18. Liu H, Ding D, Jiang H, Wu X, Salvi R, Sun H. Ototoxic destruction by co-administration of kanamycin and ethacrynic acid in rats. Journal of Zhejiang University-Science b (biomedicine & biotechnology) 2011; 12(10):853-61.


  19. Shen Z, Zheng J, Peng G, Zhang T, Gong S, Zhu Y, et al. Frequency and spectrum of mitochondrial 12S rRNA variants in 440 han chinese hearing impaired pediatric subjects from two otology clinics. Journal of Translational Medicine 2011; 9:15-21.


  20. Van de water TR, Rybak LP. Ototoxic damage to hearing: otoprotective therapies. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 170-8.


  21. Wang Q, Steyger PS. Trafficking of systemic fluorescent gentamicin into the cochlea and hair cells. Journal of the Association for Research in Otolaryngology 2009; 10:205-19.


  22. Roland PS, Wright CG. Topical aminoglycoside cochlear ototoxicity. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 114-9.


  23. Prepageran N, Kisilevsky V, Rutka JA. Topical aminoglycoside vestibular toxicity. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 121-6.


  24. Campbell KCM. Audiologic monitoring for ototoxicity. In: Roland PS, Rutka JA, eds. Ototoxicity. 1st ed. London: BC Decker Inc; 2004. p. 153-7.


  25. Dhillon RS, East CA. Disorders of balance. In: Marks S, ed. Ear, nose and throat and head and neck surgery. 2nd edition. United Kingdom: Churchill Livingstone; 2000. p. 20-2.


Published
2019-12-17
How to Cite
FRANSISKA, Fransiska. Ototoksisitas Aminoglikosida. KELUWIH: Jurnal Kesehatan dan Kedokteran, [S.l.], v. 1, n. 1, p. 37-47, dec. 2019. ISSN 2715-6419. Available at: <https://www.journal.ubaya.ac.id/index.php/kesdok/article/view/2495>. Date accessed: 03 aug. 2020. doi: https://doi.org/10.24123/kesdok.V1i1.2495.